Products
RENALASE antibody
- Product Name
- RENALASE antibody
- Catalogue No.
- FNab07238
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- chromosome 10 open reading frame 59
- Alternative Names
- C10orf59 antibody, MAO C antibody, Monoamine oxidase C antibody, RENALASE antibody, RNLS antibody
- UniProt ID
- Q5VYX0
- Observed MW
- 35 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000
Validated Images
human heart tissue were subjected to SDS PAGE followed by western blot with FNab07238(RENALASE antibody) at dilution of 1:500
IP Result of anti-RENALASE (IP:FNab07238, 4ug; Detection:FNab07238 1:500) with HEK-293 cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human kidney using FNab07238(RENALASE antibody) at dilution of 1:100
- Background
- RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity.(PMID:15841207) This antibody is specific to RNLS.
